All Articles

A Prospective, Controlled Study of the Botanical Compound Mixture LCS101 for Chemotherapy-Induced Hematological Complications in Breast Cancer

This prospective, controlled study evaluated the safety, tolerability, and efficacy of the mixture of botanical compounds known as LCS101 in preventing chemotherapy-induced hematological toxicity in breast cancer patients.
The addition of LCS101 to anthracycline- and taxane-based chemotherapy is safe and well tolerated, and may significantly prevent some chemotherapy-induced hematological toxicities in early breast cancer patients.

Posted on: The Oncologist. 2011;16:1197-202

author: Yaal-Hahoshen N, Maimon Y, Siegelmann-Danieli N, Lev-Ari S, Ron IG, Sperber F, Samuels N, Shoham J, Merimsky O.

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Immunomodulatory effects of the botanical compound LCS101: implications for cancer treatment.

LCS101 preparations were tested for batch-to-batch consistency using high-performance liquid chromatography. T-cell activation was quantified in murine spleen cells using 3H-thymidine incorporation, and cytokine production analyzed with enzyme-linked immunosorbent assay. Natural killer cell activity was tested on human blood cells using flow cytometry, and cytotoxicity measured by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide and apoptosis using a FACSCalibur. Effects on interferon-γ production in fluorouracil/doxorubicin-treated mice were tested with enzyme-linked immunosorbent assay.

Posted on: OncoTargets and Therapies 2013; 6:437-45.

author: Rachmut IH, Samuels N, Melnick SJ, Ramachandran C, Sharabi Y, Pavlovsky A, Maimon Y, Shoham J.

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Non-herbal nutritional supplements for symptom relief in adjuvant breast cancer: creating a doctor-patient dialogue.

Patients with breast cancer frequently turn to complementary medical therapies, including non-herbal nutritional supplements (NHNS). A number of NHNS products have been shown to potentially reduce the incidence and severity of adjuvant treatment-related symptoms. We review the literature and summarise the potential beneficial effects of these products and address issues regarding the safety of this practice.
There is a need to develop an open and non-judgmental dialogue between doctors and their patients with breast cancer, respecting the needs of the patient while addressing issues related to the efficacy and safety of NHNS products. Referral of patients to an integrative medicine consultant may help achieve these goals.

Posted on: British Medical Journal: Supportive and Palliative Care. 2014; 4:e1

author: Samuels N, Schiff E, Ben-Arye E

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Advising patients on the use of non-herbal nutritional supplements during cancer therapy: a need for doctor-patient communication.

Many cancer patients are using non-herbal nutritional supplements (NHNS), often without informing their oncologists.
There is a need to develop an open and nonjudgmental dialogue between oncologists and cancer patients, addressing the needs of the patient while dealing with issues related to the efficacy and safety of these products. Referral of patients to an integrative medicine consultant may help achieve these goals, providing both parties with the option of reaching an informed and respectful decision about treatment.

Posted on: J Pain Symptom Manage. 2013 Dec;46(6):887-96

author: Ben-Arye E, Polliack A, Schiff E, Tadmor T, Samuels N

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Homeopathy on the crossroads of traditional and integrative medicine in the Middle-East

The Middle-East is characterized by a rich spectrum of complementary and traditional medicine therapies, which are used by patients in parallel with conventional medicine. Indigenous traditional medicine practices in the region focus mainly on herbal medicine and far less on the use of European-based complementary medicine modalities such as homeopathy. Little has been reported on the extent to which homeopathy is being used in the Middle-East, this despite an emerging body of basic science and clinical research on the subject from countries such as Egypt, Iran, Iraq, Israel, and Lebanon. We compare the foundations of homeopathy with those of traditional Middle-Eastern medicine in the Middle-East, and explore the possibilities of collaborative research and clinical practice. In particular, qualitative research is warranted to explore patients’ expectations regarding homeopathic consultation and feasibility of its integration into Middle-Eastern health systems. Studying patient–homeopath communication patterns may be used to promote the clinical implementation of patient-centered care, based on a bio-psycho-social-spiritual health model.

Posted on: Journal of Medicine and the Person 2015; 13: 65-71

author: Ben-Arye E, Samuels N

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Patient-centered care in lung cancer: exploring the next milestones

In this editorial, the authors comment on a recently published review paper by Molassiotis et al. on the developments made over the past 40 years in supportive care for patients with lung cancer. During this period, a paradigm shift promoting patient-centered care (PCC) has led to an important change in the approach of supportive cancer care, from a purely disease-centered approach, measuring survival-related outcomes, to recognizing the importance of quality of life outcomes as well. This change of understanding in supportive and palliative care for patients with lung cancer can be further advanced through the understanding that there is a need to address bio-psycho-spiritual concerns and health belief models, within the context of the family socio-cultural environment, for both patients and their caregivers. There is also a need to address the psycho-spiritual effects of cancer on those health care professionals treating patients with lung cancer, in order to reduce compassion fatigue and increase resilience. Future directions for supportive care for patients with lung cancer may include the development of a patient-tailored treatment approach, assisted by the integration of a multidisciplinary team of health care providers and evidence-based complementary medicine practices, within conventional supportive care practice.

Posted on: Translational Lung Cancer Research 2015; in press

author: Ben-Arye E, Samuels N

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Use of herbal medicine for cancer treatment-related toxicities

The article presents three case series in which cancer patients were treated with medicinal herbs and showed significant decrease in chemotherapy-related side effects, alongside improvement in quality of life. In these case series, the use of medicinal herbs allowed patients to complete the conventional oncology treatment program to full recovery.

Posted on: Harefuah 2015; 154: 43-6, 67

author: Samuels N, Morag O, Maimon Y

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Use of a structured integrative oncology evaluation as a tool to improve patient adherence to a complementary medicine treatment program

This article presents the results of an integrative oncology program in which cancer patients were given complementary treatments. Two types of patients were examined: Patients who often consult with integrative physicians and patients who seldom do. The study examined patients' receptivity to the integrative process. Research showed that patients who had trust in complementary medicine and had received such treatments previous to their illness, were more receptive to the integrative healing process.

Posted on: Harefuah 2015; 154: 21-5, 69

author: Kruger D, Schiff E, Samuels N, Keinan-Bokers L, Shalom T, Ben-Arye E

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Quality-of-life outcomes in patients with gynecologic cancer referred to integrative oncology treatment during chemotherapy

Integrative oncology incorporates complementary medicine (CM) therapies in patients with cancer. We explored the impact of an integrative oncology therapeutic regimen on quality-of-life (QOL) outcomes in women with gynecological cancer undergoing chemotherapy.
An IP-guided CM treatment regimen provided to patients with gynecological cancer during chemotherapy may reduce cancer-related fatigue and improve other QOL outcomes.

Posted on: Supportive Care in Cancer 2015; published March 10

author: Ben-Arye E, Samuels N, Schiff E, Raz OG, Sharabi IS, Lavie O

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Alleviating gastro-intestinal symptoms and concerns by integrating patient-tailored complementary medicine in supportive cancer care

Chemotherapy-induced gastrointestinal (GI) toxicities often impair quality-of-life (QOL) and require reduction of the chemotherapy dose intensity. We explored the effects of a complementary integrative medicine (CIM) therapeutic process, administered in conjunction with conventional supportive care, on GI-related symptoms and concerns in patients undergoing chemotherapy.

Posted on: Clinical Nutrition 2014; S0261-5614(14)00309-4

author: Ben-Arye E, Aharonson ML, Schiff E, Samuels N

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Selective anticancer effects and protection from chemotherapy by the botanical compound LCS101: Implications for cancer treatment.

The article examines the influence of herbal formula LCS101 on cancer cells as opposed to healthy cells. It was found that the herbal formula causes death of cancerous cells (apoptosis) without any damage to healthy cells; i.e. selective targeting of cancer. Additionally, the influence of the formula in presence and in absence of chemotherapeutic medicines was examined (FU, 5 Doxorubicin). In this case too selective activity was observed, as the formula protected healthy cells from the damage caused by chemotherapy, while increasing the destruction of cancer cells in conjunction with chemotherapy.

Posted on: International Journal of Oncology 2014 (article in press)

author: Cohen Z, Maimon Y, Yoeli-Lerner M, Yang P, Samuels N, Berger R

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Expectations from an integrative medicine consultation in breast cancer care: a registry protocol-based study.

The purpose of this study is to compare the rationale given by oncology health care practitioners (HCPs) for referral of their patients with breast cancer to a complementary medicine (CM) consultation with patient expectations from the CM treatment process.

Posted on: Supportive Care in Cancer 2015; 23: 317-24

author: Samuels N, Schiff E, Lavie O, Raz OG, Ben-Arye E

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Giving voice to cancer patients: assessing non-specific effects of an integrative oncology therapeutic program via short patient narratives.

The aim of this study was to assess patient perspectives regarding non-specific effects of a complementary medicine (CM) consultation and intervention within an integrative oncology setting.

Posted on: Psychooncology 2015; 24: 169-74

author: Keshet Y, Schiff E, Samuels N, Ben-Arye E

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